Hydrochloric Acid → HCID 21473658, compound

HRID 2294052Notes

Reaction equation

HRID 2294052 reaction equation
Cl.[Cl:2][C:3]1[CH:4]=[C:5]([C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]3)[CH:6]=[C:7]([Cl:9])[CH:8]=1>C(OCC)(=O)C>[ClH:2].[Cl:2][C:3]1[CH:4]=[C:5]([C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[CH2:16][NH:15][CH2:14][CH2:13]3)[CH:6]=[C:7]([Cl:9])[CH:8]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21473615HCID 21473615, compound

Product 1

HCID 21473658HCID 21473658, compoundYield 91%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A stream of hydrogen chloride gas was conducted through a solution of 3.42 g (0.0904 mol) of tert.-butyl 6-(3,5-dichloro-phenyl)-3,4-dihydro-1H-isoquinoline-2-carboxylate in 180 ml of ethyl acetate. The reaction was followed by thin-layer chromatography. The mixture was cooled to 0° and suction filtered. 2.58 g (91%) of 6-(3,5-dichlorophenyl)-3,4-dihydro-1H-isochinoline hydrochloride were obtained as white crystals; m.p. 220°-260° (dec.).

Workup

  1. temperatureThe mixture was cooled to 0°
  2. filtrationsuction filtered

Sources & evidence

ORD record
ord-a3486ac952404bf494796a2784b193ce
Source dataset
uspto-grants-1997_11
Patent number
US05688798

Reaction notes

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