反应详情

To 150 ml of a tetrahydrofuran suspension containing 10 g of trans-4-aminocyclohexanol was added 15ml of triethylamine, 50 ml of a tetrahydrofuran solution containing 2-chloro-5-nitropyridine was further added thereto under ice-cooling, and then, the mixture was stirred at room temperature for 18 hours. Water was added to the reaction mixture and the mixture was extracted with chloroform. The extract was washed with brine, dried over anhydrous sodium sulfate, and the solvent was removed under reduced pressure. The residue was purified by silica gel flash column chromatography (solvent: ethyl acetate-hexane (2:1)) to obtain 8.52 g of trans-4-(5-nitro-2-pyridylamino)cyclohexanol.

1. additionwas further added
2. temperatureunder ice-cooling
3. extractionthe mixture was extracted with chloroform
4. washThe extract was washed with brine
5. dry with materialdried over anhydrous sodium sulfate
6. customthe solvent was removed under reduced pressure
7. customThe residue was purified by silica gel flash column chromatography (solvent: ethyl acetate-hexane (2:1))