反应详情

A mixture of benzyl 3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino-formate dihydrochloride (481 g, 1.05 mol) and potassium carbonate (630 mL, 5.5N, 3.15 mol) in 4L of ethyl acetate was stirred at room temperature for 1 hour. The mixture was washed with water (1×630 mL), treated with silica gel (200 g) and filtered. The filtrate was concentrated under reduced pressure to give benzyl 3-[4-(2-methoxyphenyl)piperazin-1-yl]propylaminoformate (385.9 g, 1.01 mol) as an oil.

1. washThe mixture was washed with water (1×630 mL)
2. additiontreated with silica gel (200 g)
3. filtrationfiltered
4. concentrationThe filtrate was concentrated under reduced pressure