Sodium Hydroxide → HCID 21473956, compound

HRID 2294189Notes

Reaction equation

HRID 2294189 reaction equation
[OH-].[Na+].[N+:3]([C:6]1[C:7]([N:21]2[CH2:25][CH2:24][CH2:23][CH2:22]2)=[CH:8][C:9]2[C:10]3[N:11]([C:17](=[O:20])[NH:18][N:19]=3)[C:12](=[O:16])[NH:13][C:14]=2[CH:15]=1)([O-:5])=[O:4]>CN(C)C=O>[N+:3]([C:6]1[C:7]([N:21]2[CH2:25][CH2:24][CH2:23][CH2:22]2)=[CH:8][C:9]2[C:10]3[N:19]([NH:18][C:17](=[O:20])[N:11]=3)[C:12](=[O:16])[NH:13][C:14]=2[CH:15]=1)([O-:5])=[O:4]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 136395959HCID 136395959, compound

Product 1

HCID 21473956HCID 21473956, compoundYield 96.9%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

9.86 ml of 0.1M NaOH were added to a solution of 200 mg (0.63 mmol) of 8-nitro-9-pyrrolidin-1-yl-2,3,5,6-tetrahydro[1,2,4]triazolo[4,3-c]quinazoline-3,5-dione and 20 ml of dimethylformamide and the mixture was stirred at room temperature for 30 min. Subsequently, the mixture was concentrated to dryness, treated 3 times with deionized water and again concentrated. The residue was dried in a high vacuum. There were obtained 193 mg (90%) of 8-nitro-9-pyrrolidin-1-yl-2,3,5,6-tetrahydro-[1,2,4]triazolo[1,5-c]quinazoline-2,5-dione as a red-brown powder.

Workup

  1. concentrationSubsequently, the mixture was concentrated to dryness
  2. additiontreated 3 times with deionized water
  3. concentrationagain concentrated
  4. customThe residue was dried in a high vacuum

Sources & evidence

ORD record
ord-2a3bf01b373346f691ecf14c1e4dbdcc
Source dataset
uspto-grants-1997_11
Patent number
US05688803

Reaction notes

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