Ethanol → HCID 178518843, compound

HRID 2294200Notes

Reaction equation

HRID 2294200 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([Cl:8])[C:5]([Cl:9])=[CH:4][C:3]=1[C:10]1[NH:14][NH:13][C:12](=[O:15])[C:11]=1[C:16]([O:18]CC)=O.C(O)C>CN(C)C=O>[Cl:8][C:6]1[C:5]([Cl:9])=[CH:4][C:3]2[C:10]3[NH:14][NH:13][C:12](=[O:15])[C:11]=3[C:16]([OH:18])=[N:1][C:2]=2[CH:7]=1

Participants

4

Reactant 2

HCID 702EthanolHCID 21473962HCID 21473962, compound

Product 1

HCID 178518843HCID 178518843, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

0.63 g (0.002 mol) of ethyl 5-(2-amino-4,5-dichlorophenyl)-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate was dissolved in 10 ml of dimethylformamide and boiled under reflux for 1/2 hr. The mixture was cooled, the suspension was treated with 50 ml of ethanol, suction filtered and dried in a vacuum. Yield: 0.18 g (33%) of 7,8-dichloro-4-hydroxy-2,3-dihydro-1H-pyrazolo[4,3-c]quinolin-3-one as beige crystals; m.p. >350° C.

Workup

  1. temperatureunder reflux for 1/2 hr
  2. temperatureThe mixture was cooled
  3. filtrationfiltered
  4. customdried in a vacuum

Sources & evidence

ORD record
ord-f7236b906084454288da6501e1925d25
Source dataset
uspto-grants-1997_11
Patent number
US05688803

Reaction notes

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