Aluminium lithium hydride → HCID 21474807, compound

HRID 2294354Notes

Reaction equation

HRID 2294354 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][CH:16]=1)[CH2:5][O:6][CH2:7][CH:8]([OH:13])[CH2:9][N:10]=[N+]=[N-].[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][CH:16]=1)[CH2:5][O:6][CH2:7][CH:8]([OH:13])[CH2:9][NH2:10]

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 21474758HCID 21474758, compound

Product 1

HCID 21474807HCID 21474807, compoundYield 60.7%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A procedure similar to that described in Preparation 13 was repeated, except that 6.22 g of 3-(3-chlorobenzyloxy)-2-hydroxypropylazide (prepared as described in Preparation 92), 1.97 g of lithium aluminum hydride and 120 ml of anhydrous tetrahydrofuran were used, to give 3.37 g of the title compound having an Rf value of 0.03 (on silica gel thin layer chromatography, using a mixture of ethyl acetate as the developing solvent).

Workup

  1. customA procedure similar to that described in Preparation 13

Sources & evidence

ORD record
ord-080df108fe3c45d1a689474b42681ad2
Source dataset
uspto-grants-1997_11
Patent number
US05688823

Reaction notes

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