N-Iodosuccinimide → Methyl 3-iodoimidazo[1,2-a]pyridine-7-carboxylate

HRID 229441ノート

反応式

HRID 229441 の反応式
C1C(=O)N([I:8])C(=O)C1.[CH3:9][O:10][C:11]([C:13]1[CH:18]=[CH:17][N:16]2[CH:19]=[CH:20][N:21]=[C:15]2[CH:14]=1)=[O:12]>C(#N)C>[CH3:9][O:10][C:11]([C:13]1[CH:18]=[CH:17][N:16]2[C:19]([I:8])=[CH:20][N:21]=[C:15]2[CH:14]=1)=[O:12]

参加物

4

反応物 2

HCID 120273N-IodosuccinimideHCID 15096964Methyl imidazo(1,2-a)pyridine-7-carboxylate

生成物 1

HCID 57497695Methyl 3-iodoimidazo[1,2-a]pyridine-7-carboxylate収率 88%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

NIS (1.5 eq, 1.06 mmol, 238 mg) was added in one portion to a stirred solution of imidazo[1,2-a]pyridine-7-carboxylic acid methyl ester (0.705 mmol, 124 mg) in acetonitrile (3 mL). The resulting mixture was stirred overnight. The resulting precipitate was filtered and washed with ethyl acetate. Drying in vacuo at room temperature afforded 3-iodo-imidazo[1,2-a]pyridine-7-carboxylic acid methyl ester in 88% yield. m/z (M+H)=303.1.

後処理

  1. filtrationThe resulting precipitate was filtered
  2. washwashed with ethyl acetate
  3. customDrying in vacuo at room temperature

出典と根拠

ORDレコード
ord-efda8afd4367441fb36d3814e5cbd0a8
出典データセット
uspto-grants-2009_07
特許番号
US07563797B2

反応ノート

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