Hydrochloric Acid → 4-(Hydroxymethyl)benzaldehyde

7.9 g (44 mmol) of the above alcohol and 100 ml of THF are introduced into a round-bottomed flask, 20 ml of hydrochloric acid (1N) are added and the mixture is heated to reflux for 4 h. The reaction medium is evaporated to dryness, the residue is taken up with ethyl ether and saturated sodium bicarbonate solution and the organic phase is separated after settling has taken place, dried over magnesium sulphate and evaporated.

1. temperaturethe mixture is heated
2. temperatureto reflux for 4 h
3. customThe reaction medium is evaporated to dryness
4. customthe organic phase is separated after settling
5. dry with materialdried over magnesium sulphate
6. customevaporated

ORD record

ord-239c6aad617e4dd99f3943b9304e97f2

Source dataset

uspto-grants-1997_11

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05688817