Potassium Carbonate → HCID 21469848, compound

HRID 2295137Notes

Reaction equation

HRID 2295137 reaction equation
[OH:1][C:2]1[CH:15]=[CH:14][C:5]([C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[O:7])=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].Br[CH2:23][CH2:24][CH2:25][CH2:26][Cl:27]>CC(C)=O>[Cl:27][CH2:26][CH2:25][CH2:24][CH2:23][O:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[O:7])=[CH:14][CH:15]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 143474-HydroxybenzophenoneHCID 813641-Bromo-4-chlorobutane

Product 1

HCID 21469848HCID 21469848, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Combine 4-hydroxybenzophenone (8 kg, 57,6 mol), potassium carbonate (8 kg, 57.6 mol), and 1-bromo-4-chlorobutane (8.384 kg, 48.9 mol) in acetone (40 L). Heat to reflux. After 20 hours, cool the reaction mixture and filter. Rinse the filter cake with acetone and evaporate the filtrate in vacuo to obtain 4-(4-chlorobutoxy) benzophenone.

Workup

  1. temperatureHeat to reflux
  2. temperaturecool the reaction mixture
  3. filtrationfilter
  4. washRinse the filter cake with acetone
  5. customevaporate the filtrate in vacuo

Sources & evidence

ORD record
ord-e6f2ee4925214997bb90652433800a5e
Source dataset
uspto-grants-1997_11
Patent number
US05691384

Reaction notes

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