Diethyl Ether → 2-Amino-4'-fluorobenzophenone

Temperature

0 °C

A dry 500 ml 3-neck flask fitted with a reflux condenser and an addition funnel was charged with Mg turnings (2.80 gm, 0.115 mol) and dry Et2 O (35 ml). A solution of 1-bromo-4-fluorobenzene (18.5 gm, 0.106 mol) in Et2O (20 ml) was added to the addition funnel and approximately 15% of this solution was added to the Mg/Et2O mixture. Once the exothermic reaction had begun (ultrasound was required), the aryl bromide solution was added at such a rate as to maintain a gentle reflux. After the addition was complete, the mixture was refluxed for an additional 30 minutes, then cooled to 0° C. Dropwise addition of a solution of 2-aminobenzonitrile (5.00 gm, 0.042 mol) in dry Et2O (20 ml) over a 10 minute period resulted in the formation of a thick yellow slurry. The resulting mixture was warmed to room temperature and stirred overnight. The solution was then cooled to 0° C. and cautiously quenched with 10% HCl (50 ml). After stirring for 5 minutes, the solution was made basic with 10% NaOH (70 ml) and the aqueous layer was extracted three times with Et2O. The combined Et2O layers were pooled, washed with brine, dried (Na2SO4), filtered and stripped to yield an orange oil. The oil was chromatographed (Flash, Merck SiO2, 25% EtOAc in hexane) to give impure 2-aminophenyl 4-fluorophenyl methanone (~1 gm) and the corresponding impure imine (~5.8 gm, Rf 0.28 in 30% EtOAc in hexane). The imine was stirred with 10% HCl (100 ml) and silica gel (750 mg) for 45 minutes. The mixture was then basicified with NaOH pellets (14 gm) and the aqueous layer was extracted twice with Et2O. The combined Et2O layers were washed with brine, dried (Na2 SO4), filtered and stripped to yield a solid. This solid was pooled with impure 2-aminophenyl 4-fluorophenyl methanone from above and recrystallized in hot EtOH/H2O to give analytically pure 2-aminophenyl 4-fluorophenyl methanone as yellow crystals (3.28 gm, 36%).

1. customA dry 500 ml 3-neck flask fitted with a reflux condenser and an addition funnel
2. customdry Et2 O (35 ml)
3. customOnce the exothermic reaction
4. temperatureto maintain a gentle reflux
5. additionAfter the addition
6. temperaturethe mixture was refluxed for an additional 30 minutes
7. customresulted in the formation of a thick yellow slurry
8. temperatureThe resulting mixture was warmed to room temperature
9. temperatureThe solution was then cooled to 0° C.
10. customcautiously quenched with 10% HCl (50 ml)
11. stirringAfter stirring for 5 minutes
12. extractionthe aqueous layer was extracted three times with Et2O
13. washwashed with brine
14. dry with materialdried (Na2SO4)
15. filtrationfiltered
16. customto yield an orange oil
17. customThe oil was chromatographed (Flash, Merck SiO2, 25% EtOAc in hexane)

ORD record

ord-f073889192ec4905b95ca0111dc4b131

Source dataset

uspto-grants-1997_11

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05691322