Hydrochloric Acid → HCID 20475065, compound

HRID 2295281Notes

Reaction equation

HRID 2295281 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([NH:8][C:9]([N:11]2[C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=3[C:15](=[O:22])[NH:14][C:13]3[CH:23]=[CH:24][CH:25]=[N:26][C:12]2=3)=[O:10])[CH2:4][CH2:3]1.[ClH:27]>C(O)C>[OH2:10].[ClH:27].[CH3:1][N:2]1[CH2:3][CH2:4][N:5]([NH:8][C:9]([N:11]2[C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=3[C:15](=[O:22])[NH:14][C:13]3[CH:23]=[CH:24][CH:25]=[N:26][C:12]2=3)=[O:10])[CH2:6][CH2:7]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 13271741HCID 13271741, compound

Product 1

HCID 20475065HCID 20475065, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1 g of 5,11-dihydro-11-[[(4-methyl-1-piperazinyl)amino]carbonyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one was dissolved in a little ethanol and mixed with ethanolic hydrochloric acid. The mixture was concentrated greatly by evaporation and then acetone was added. The precipitate was recrystallized from ethanol. After air-drying 0.8 g of 5,11-dihydro-11-[[(4-methyl-1-piperazinyl)amino]carbonyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one hydrochloride hydrate were obtained;

Workup

  1. concentrationThe mixture was concentrated greatly by evaporation
  2. additionacetone was added
  3. customThe precipitate was recrystallized from ethanol
  4. dry with materialAfter air-drying 0.8 g of 5,11-dihydro-11-[[(4-methyl-1-piperazinyl)amino]carbonyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one hydrochloride hydrate
  5. customwere obtained

Sources & evidence

ORD record
ord-d2f3dd55db404958a9bfc4d5e77b0bad
Source dataset
uspto-grants-1984_01
Patent number
US04424222

Reaction notes

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