Butyl iodide → Ethyl 2-(butoxyimino)-3-oxobutanoate

HRID 2295550Notes

Reaction equation

HRID 2295550 reaction equation
[CH2:1](I)[CH2:2][CH2:3][CH3:4].[OH:6][N:7]=[C:8]([C:14](=[O:16])[CH3:15])[C:9]([O:11][CH2:12][CH3:13])=[O:10].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH2:1]([O:6][N:7]=[C:8]([C:14](=[O:16])[CH3:15])[C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH2:2][CH2:3][CH3:4]

Participants

5

Reactant 3

HCID 10962Butyl iodideHCID 11430Potassium CarbonateHCID 178472877HCID 178472877, compound

Product 1

HCID 53974956Ethyl 2-(butoxyimino)-3-oxobutanoateYield 90.2%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

n-Butyl iodide (46.9 g.) was added dropwise to a stirred suspension of ethyl 2-hydroxyimino-3-oxobutyrate (syn isomer, 40 g.), potassium carbonate (52.7 g.) and acetone (200 ml.) under ice-cooling over 5 minutes, and stirred at room temperature for 4 hours. The resultant solution was filtered, and washed with acetone. The filtrate and washing solution were combined together and concentrated in vacuo. After adding water (300 ml.) to the residue, the solution was extracted with methylene chloride three times. The solution was washed with a saturated aqueous solution of sodium chloride, dried over magnesium sulfate and concentrated in vacuo to give ethyl 2-n-butoxyimino-3-oxobutyrate (syn isomer, 48.8 g.), oil.

Workup

  1. temperaturecooling over 5 minutes
  2. filtrationThe resultant solution was filtered
  3. washwashed with acetone
  4. washThe filtrate and washing solution
  5. concentrationconcentrated in vacuo
  6. additionAfter adding water (300 ml.) to the residue
  7. extractionthe solution was extracted with methylene chloride three times
  8. washThe solution was washed with a saturated aqueous solution of sodium chloride
  9. dry with materialdried over magnesium sulfate
  10. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-5536f28cad5540108f40564f8d0847d3
Source dataset
uspto-grants-1984_01
Patent number
US04425341

Reaction notes

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