反应详情

温度

32.5 °C

A 250 ml flask equipped with overhead stirrer and gas inlet was charged with 34 g of bupropion base and 138 ml of isopropanol. The solution was maintained under stirring while 13 g of gaseous HBr was introduced through the gas inlet in a time of 20′ while the internal temperature of the mixture raises from 25 to 40° C. During the gas addition a heavy white precipitate formed. At the end of the gas addition the temperature of the mixture was raised to reflux (80° C.), to get complete solution of the suspended solid. The temperature was then lowered to 25° C. in 1 hour and further lowered to 0-5° C. in 1 additional hour. The precipitate obtained was filtered and washed with 20 ml of cold isopropanol. The discharged wet solid was dried under vacuum (30 mmHg) in a static drier at 50° C. for 16 hours. 34 g of bupropion hydrobromide form I were obtained.

1. customA 250 ml flask equipped with overhead stirrer and gas inlet
2. temperatureThe solution was maintained
3. additionDuring the gas addition a heavy white precipitate
4. customformed
5. additionAt the end of the gas addition the temperature of the mixture
6. temperaturewas raised
7. temperatureto reflux (80° C.)
8. customto get complete solution of the suspended solid
9. customfurther lowered to 0-5° C. in 1 additional hour
10. customThe precipitate obtained
11. filtrationwas filtered
12. washwashed with 20 ml of cold isopropanol
13. customThe discharged wet solid was dried under vacuum (30 mmHg) in a static drier at 50° C. for 16 hours