反应详情

To 20 ml of tetrahydrofuran were added 2.4 g of 4-amino-6,7-dimethoxy-2-(1-piperazinyl)quinazoline hydrochloride and 2.6 of triethylamine, after which the mixture was stirred for 20 minutes. There was then added 0.78 g of 2-pentenoyl chloride, after which the mixture was stirred at room temperature for 15 hours. The resulting crystals were collected by filtration, washed with water and recrystallized from ethanol, to give 1.23 g of the desired Compound No. 5 in the form of pale brown needles melting at 246°-247° C.

1. stirringafter which the mixture was stirred at room temperature for 15 hours
2. filtrationThe resulting crystals were collected by filtration
3. washwashed with water
4. customrecrystallized from ethanol