3-(Trifluoromethyl)phenol → HCID 12848948, compound

HRID 2296332Notes

Reaction equation

HRID 2296332 reaction equation
[F:1][CH2:2][C:3]([CH2:9][F:10])([CH3:8])[C:4](=[O:7])[CH2:5]Br.[F:11][C:12]([F:21])([F:20])[C:13]1[CH:14]=[C:15]([OH:19])[CH:16]=[CH:17][CH:18]=1.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[F:1][CH2:2][C:3]([CH2:9][F:10])([CH3:8])[C:4](=[O:7])[CH2:5][O:19][C:15]1[CH:16]=[CH:17][CH:18]=[C:13]([C:12]([F:11])([F:20])[F:21])[CH:14]=1

Participants

5

Reactant 3

HCID 73763-(Trifluoromethyl)phenolHCID 11430Potassium CarbonateHCID 130194343,3-Bisfluoromethyl-1-bromo-butan-2-one

Product 1

HCID 12848948HCID 12848948, compoundYield 70.9%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Conditions

Temperature
50 °C

Procedure

215 g (1 mole) of 3,3-bisfluoromethyl-1-bromobutan-2-one were added dropwise to a stirred mixture of 162 g (1 mole) of 3-trifluoromethylphenol and 180 g (1.3 moles) of powdered potassium carbonate in 1,200 ml of acetone at 20° to 30° C. The mixture was stirred at 50° C. for 6 hours the inorganic salt was filtered off and the filtrate was concentrated. The residue was distilled under a high vacuum. 210 g of 3,3-bisfluoromethyl-1-(3-trifluoromethylphenoxy)-butan-2-one of boiling point 114°-18° C./0.6 mm Hg were obtained. ##STR10##

Workup

  1. filtrationwas filtered off
  2. concentrationthe filtrate was concentrated
  3. distillationThe residue was distilled under a high vacuum

Sources & evidence

ORD record
ord-6e4fd619a1e64fa2b13013f5c19d4745
Source dataset
uspto-grants-1984_01
Patent number
US04428949

Reaction notes

Loading…