Hydrochloric Acid → HCID 178521387, compound

HRID 2296341Notes

Reaction equation

HRID 2296341 reaction equation
O.[NH2:2]N.C[N:5](C)[CH:6]=[CH:7][C:8]([C:10]1[CH:33]=[CH:32][CH:31]=[CH:30][C:11]=1[O:12][CH2:13][CH:14]([OH:29])[CH2:15][N:16]1[CH2:21][CH2:20][N:19]([C:22]2[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][CH:23]=2)[CH2:18][CH2:17]1)=O.Cl>C(O)C>[NH:5]1[CH:6]=[CH:7][C:8]([C:10]2[CH:33]=[CH:32][CH:31]=[CH:30][C:11]=2[O:12][CH2:13][CH:14]([OH:29])[CH2:15][N:16]2[CH2:21][CH2:20][N:19]([C:22]3[CH:23]=[CH:24][C:25]([Cl:28])=[CH:26][CH:27]=3)[CH2:18][CH2:17]2)=[N:2]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 24654Hydrazine hydrate (1:1)HCID 56627760HCID 56627760, compound

Product 1

HCID 178521387HCID 178521387, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

15 ml of hydrazine hydrate are added to 8.0 g (0.017 mole) of 1-[2-(3-Dimethylamino-1-oxo-propenyl)-phenoxy]-3-[4-(4-chlorophenyl)-piperazin-1-yl]-propan-2-ol.HCl (Example 4b) in 100 ml of ethanol, and the mixture is refluxed for 3 days. The solvent is distilled off and the residue is recrystallized from ethanol. 6.2 g (88%) of a product of melting point 120°-121° C. are isolated.

Workup

  1. distillationThe solvent is distilled off
  2. customthe residue is recrystallized from ethanol

Sources & evidence

ORD record
ord-deb01e27dc3744f889de727821f6a2ee
Source dataset
uspto-grants-1984_01
Patent number
US04428950

Reaction notes

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