Hydrochloric Acid → HCID 70514525, compound

HRID 2296360Notes

Reaction equation

HRID 2296360 reaction equation
[NH2:1][C:2]1[C:3]([C:10]([OH:12])=[O:11])=[CH:4][S:5][C:6]=1[CH2:7][CH2:8][CH3:9].[ClH:13].[CH2:14](O)[CH3:15]>>[ClH:13].[CH2:14]([O:11][C:10]([C:3]1[C:2]([NH2:1])=[C:6]([CH2:7][CH2:8][CH3:9])[S:5][CH:4]=1)=[O:12])[CH3:15]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 132861584-Amino-5-propylthiophene-3-carboxylic acid

Product 1

HCID 70514525HCID 70514525, compound

Procedure

A sample of 1.50 g. (8.097 mmols) of 4-amino-5-propyl-3-thiophenecarboxylic acid was dissolved in 75 ml. absolute ethanol which had been previously saturated with gaseous hydrogen chloride. The resulting reaction was heated under reflux for 24 hours, cooled and evaporated to afford 1.43 g. (71%) of pure 4-amino-5-propyl-3-thiophenecarboxylic acid ethyl ester hydrochloride, m.p. 144° C. (dec.) after recrystallization from ethyl acetate.

Workup

  1. customThe resulting reaction
  2. temperaturewas heated
  3. temperatureunder reflux for 24 hours
  4. temperaturecooled
  5. customevaporated
  6. customto afford 1.43 g
  7. custom(71%) of pure 4-amino-5-propyl-3-thiophenecarboxylic acid ethyl ester hydrochloride, m.p. 144° C. (dec.) after recrystallization from ethyl acetate

Sources & evidence

ORD record
ord-d4d7f0fe0b3a4170ade8d319d8eadb8a
Source dataset
uspto-grants-1984_01
Patent number
US04428963

Reaction notes

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