Hydrochloric Acid → HCID 70515775, compound

HRID 2296361Notes

Reaction equation

HRID 2296361 reaction equation
[NH2:1][C:2]1[C:3]([C:9]([OH:11])=[O:10])=[CH:4][S:5][C:6]=1[CH2:7][CH3:8].[ClH:12].[CH:13](O)([CH3:15])[CH3:14]>>[ClH:12].[CH:13]([O:10][C:9]([C:3]1[C:2]([NH2:1])=[C:6]([CH2:7][CH3:8])[S:5][CH:4]=1)=[O:11])([CH3:15])[CH3:14]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 3776IsopropanolHCID 132861554-Amino-5-ethylthiophene-3-carboxylic acid

Product 1

HCID 70515775HCID 70515775, compound

Procedure

A sample of 1.02 g. (4.610 mmols) of 4-amino-5-ethyl-3-thiophenecarboxylic acid was dissolved in 50 ml. of isopropanol which had been previously saturated with gaseous hydrogen chloride. The resulting reaction was heated under reflux for 48 hours, cooled and evaporated to afford 0.927 g. (81%) of pure 4-amino-5-ethyl-3-thiophenecarboxylic acid isopropyl ester hydrochloride, m.p. 159° C. (dec.) after recrystallization from isopropanol/ether.

Workup

  1. customThe resulting reaction
  2. temperaturewas heated
  3. temperatureunder reflux for 48 hours
  4. temperaturecooled
  5. customevaporated
  6. customto afford 0.927 g
  7. custom(81%) of pure 4-amino-5-ethyl-3-thiophenecarboxylic acid isopropyl ester hydrochloride, m.p. 159° C. (dec.) after recrystallization from isopropanol/ether

Sources & evidence

ORD record
ord-1c52abc27833412ba0bf8c7fdfbb86a5
Source dataset
uspto-grants-1984_01
Patent number
US04428963

Reaction notes

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