Diphenyl Ether → HCID 13060557, compound

HRID 2296467Notes

Reaction equation

HRID 2296467 reaction equation
[CH:1]1([C:7]([NH:9][C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[N:16]=[CH:15][N:14]=[C:13]3[NH:20][CH:21]=[C:22]([C:27]([O:29][CH3:30])=[O:28])[C:23](OC)=[O:24])=[O:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C1(OC2C=CC=CC=2)C=CC=CC=1>>[O:24]=[C:23]1[N:14]2[CH:15]=[N:16][C:17]3[CH:18]=[CH:19][C:10]([NH:9][C:7]([CH:1]4[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]4)=[O:8])=[CH:11][C:12]=3[C:13]2=[N:20][CH:21]=[C:22]1[C:27]([O:29][CH3:30])=[O:28]

Participants

3

Reactant 2

HCID 7583Diphenyl EtherHCID 70484631HCID 70484631, compound

Product 1

HCID 13060557HCID 13060557, compoundYield 97.6%

Conditions

Temperature
260 °C

Procedure

A mixture of dimethyl [[6-cyclohexanecarboxamido-4-quinazolinylamino]methylene]propanedioate (4 g) and diphenyl ether (31 ml) was stirred at 260° C. for 15 minutes. After cooling to ambient temperature, the resulting solid was collected by filtration, washed with hexane and dried. There was obtained methyl 4-oxo-10-cyclohexanecarboxamido-4H-pyrimido[1,2-C]quinazoline-3-carboxylate (3.6 g).

Workup

  1. temperatureAfter cooling to ambient temperature
  2. filtrationthe resulting solid was collected by filtration
  3. washwashed with hexane
  4. customdried

Sources & evidence

ORD record
ord-23733e3e66284f729f67a8268e38a25e
Source dataset
uspto-grants-1984_01
Patent number
US04429126

Reaction notes

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