Diethyl Ether → HCID 20472614, compound

HRID 2296483Notes

Reaction equation

HRID 2296483 reaction equation
[O:1]=[C:2]1[N:7]2[CH:8]=[N:9][C:10]3[CH:11]=[CH:12][C:13]([NH:16][C:17](=[O:22])[C:18]([CH3:21])([CH3:20])[CH3:19])=[CH:14][C:15]=3[C:6]2=[N:5][CH:4]=[C:3]1[C:23]([OH:25])=[O:24].[CH2:26]([OH:33])C(N)(CO)CO.CC[O:36][CH2:37]C>CN(C)C=O>[O:1]=[C:2]1[N:7]2[CH:8]=[N:9][C:10]3[CH:11]=[CH:12][C:13]([NH:16][C:17](=[O:22])[C:18]([CH3:20])([CH3:21])[CH3:19])=[CH:14][C:15]=3[C:6]2=[N:5][CH:4]=[C:3]1[C:23]([O-:25])=[O:24].[OH:1][CH2:2][N+:7]([CH2:26][OH:33])([CH2:37][OH:36])[CH3:6]

Participants

5

Reactant 3

HCID 3283Diethyl EtherHCID 6503Tris(hydroxymethyl)aminomethaneHCID 13060574HCID 13060574, compound

Product 1

HCID 20472614HCID 20472614, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

4-Oxo-10-(pivalamido)-4H-pyrimido[1,2-C]quinazoline-3-carboxylic acid (1.31 g) was suspended in N,N-dimethylformamide (13 ml). To this suspension was added tris (hydroxymethyl)aminomethane (0.466 g) at ambient temperature. After one hour, the starting material was dissolved completely. To this solution ether was added and the precipitated crystals were collected by filtration and washed with ether to give tris-(hydroxymethyl)methyl-ammonium 4-oxo-10-(pivalamido)-4H-pyrimido[1,2-C]quinazoline-3-carboxylate (1.63 g).

Workup

  1. dissolutionthe starting material was dissolved completely
  2. filtrationthe precipitated crystals were collected by filtration
  3. washwashed with ether

Sources & evidence

ORD record
ord-b71b6fd407d1406f979a37a9df4a3792
Source dataset
uspto-grants-1984_01
Patent number
US04429126

Reaction notes

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