Sodium hydride → HCID 56987812, compound

HRID 2296699Notes

Reaction equation

HRID 2296699 reaction equation
[NH2:1][C:2]1[C:7]([C:8]([OH:20])([C:13]#[C:14][C:15]2OC=[CH:18][CH:19]=2)[C:9]([F:12])([F:11])[F:10])=[CH:6][C:5]([Cl:21])=[CH:4][CH:3]=1.[C:22](=[O:25])([O-])[O-].[Cs+].[Cs+].[I-].[Li+].[H-].[Na+]>>[Cl:21][C:5]1[CH:4]=[CH:3][C:2]2[NH:1][C:8](=[O:20])[C@H:7]([CH2:6][CH3:5])[O:20][C@:8]([C:13]#[C:14][C:15]3[CH:19]=[CH:18][O:25][CH:22]=3)([C:9]([F:10])([F:11])[F:12])[C:7]=2[CH:6]=1

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 54107311HCID 54107311, compoundHCID 86755963HCID 86755963, compound

Product 1

HCID 56987812HCID 56987812, compound

Procedure

The title compound was prepared in a manner similar to the product of Example 11 except that cesium carbonate/lithium iodide rather than sodium hydride was used in the final reaction step: mp 169-170°; HRMS: Calcd. for C18H14NO3F3Cl (M+H)+: 384.061431. Found: 384.058632.

Workup

  1. customreaction step

Sources & evidence

ORD record
ord-2786be2bf8a44cc6b59f1c9cfb733795
Source dataset
uspto-grants-2002_12
Patent number
US06489320B1

Reaction notes

Loading…