Dimethylamine → HCID 18387451, compound

HRID 2296749Notes

Reaction equation

HRID 2296749 reaction equation
CS([CH2:5][CH2:6][CH:7]1[CH:13]=[CH:12][N:11]([C:14](=[O:31])[C:15]2[CH:20]=[CH:19][C:18]([NH:21][C:22](=[O:30])[C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=3[CH3:29])=[CH:17][CH:16]=2)[C:10]2[CH:32]=[CH:33][CH:34]=[CH:35][C:9]=2[S:8]1)(=O)=O.[OH-].[NH4+].C[NH:39]C>O1CCCC1>[NH2:39][CH2:5][CH2:6][CH:7]1[CH:13]=[CH:12][N:11]([C:14](=[O:31])[C:15]2[CH:20]=[CH:19][C:18]([NH:21][C:22](=[O:30])[C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=3[CH3:29])=[CH:17][CH:16]=2)[C:10]2[CH:32]=[CH:33][CH:34]=[CH:35][C:9]=2[S:8]1

Participants

5

Reactant 3

HCID 674DimethylamineHCID 14923Ammonium HydroxideHCID 18387453HCID 18387453, compound

Product 1

HCID 18387451HCID 18387451, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of Compound 13 as prepared in Example 10 (0.050 g, 0.09 mM) in tetrahydrofuran (4 ml) was treated as described in Example 12 with ammonium hydroxide (1 ml) substituted for dimethylamine to give a white solid product. m/z (MH+)446

Workup

  1. additionwas treated
  2. customto give a white solid product

Sources & evidence

ORD record
ord-206c04430ac24376a366bc631b6e4f56
Source dataset
uspto-grants-2002_12
Patent number
US06489321B1

Reaction notes

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