HRID2296762

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID31297

Methanesulfonyl chloride

CH3ClO2S

反应SMILES：O=C(Nc1ccc(CN2C(=O)C=C(CCO)Sc3ccccc32)cc1)c1ccccc1-c1ccccc1

HCID18387431

未命名化合物

PRODUCTS

产物

反应SMILES：CS(=O)(=O)CCC1=CC(=O)N(Cc2ccc(NC(=O)c3ccccc3-c3ccccc3)cc2)c2ccccc2S1

HCID18387446

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8471

Triethylamine

C6H15N

PROCEDURE

实验过程

Methanesulfonyl chloride (0.04 ml, 0.55 mM) was added to Compound 23 as prepared in Example 22 (0.280 g, 0.55 mM) and triethylamine (0.15 ml, 1.1 mM) following the procedure described in Example 29 to give the solid product. m/z (MH+) 587.

WORKUP

后处理

customto give the solid product

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-167bef7bac0f4dd1a67def772b7a1a00
来源数据集: uspto-grants-2002_12
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US06489321B1
来源说明: uspto-grants-2002_12

反应SMILES

[CH3:1][S:2](Cl)(=[O:4])=[O:3].O[CH2:7][CH2:8][C:9]1[S:10][C:11]2[CH:42]=[CH:41][CH:40]=[CH:39][C:12]=2[N:13]([CH2:17][C:18]2[CH:23]=[CH:22][C:21]([NH:24][C:25](=[O:38])[C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=3[C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)=[CH:20][CH:19]=2)[C:14](=[O:16])[CH:15]=1>C(N(CC)CC)C>[CH3:1][S:2]([CH2:7][CH2:8][C:9]1[S:10][C:11]2[CH:42]=[CH:41][CH:40]=[CH:39][C:12]=2[N:13]([CH2:17][C:18]2[CH:19]=[CH:20][C:21]([NH:24][C:25](=[O:38])[C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=3[C:32]3[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=3)=[CH:22][CH:23]=2)[C:14](=[O:16])[CH:15]=1)(=[O:4])=[O:3]