Methanesulfonyl chloride → HCID 18387446, compound

HRID 2296762Notes

Reaction equation

HRID 2296762 reaction equation
[CH3:1][S:2](Cl)(=[O:4])=[O:3].O[CH2:7][CH2:8][C:9]1[S:10][C:11]2[CH:42]=[CH:41][CH:40]=[CH:39][C:12]=2[N:13]([CH2:17][C:18]2[CH:23]=[CH:22][C:21]([NH:24][C:25](=[O:38])[C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=3[C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)=[CH:20][CH:19]=2)[C:14](=[O:16])[CH:15]=1>C(N(CC)CC)C>[CH3:1][S:2]([CH2:7][CH2:8][C:9]1[S:10][C:11]2[CH:42]=[CH:41][CH:40]=[CH:39][C:12]=2[N:13]([CH2:17][C:18]2[CH:19]=[CH:20][C:21]([NH:24][C:25](=[O:38])[C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=3[C:32]3[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=3)=[CH:22][CH:23]=2)[C:14](=[O:16])[CH:15]=1)(=[O:4])=[O:3]

Participants

4

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 18387431HCID 18387431, compound

Product 1

HCID 18387446HCID 18387446, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

Methanesulfonyl chloride (0.04 ml, 0.55 mM) was added to Compound 23 as prepared in Example 22 (0.280 g, 0.55 mM) and triethylamine (0.15 ml, 1.1 mM) following the procedure described in Example 29 to give the solid product. m/z (MH+) 587.

Workup

  1. customto give the solid product

Sources & evidence

ORD record
ord-167bef7bac0f4dd1a67def772b7a1a00
Source dataset
uspto-grants-2002_12
Patent number
US06489321B1

Reaction notes

Loading…