反应详情

A mixture of (5R,6S)-1,1-diisopropoxy-5-(2,2,2-trichloroethoxycarbonyloxy)-2,2,6-trimethyl-8-nonen-3-one (4.3 g) and p-toluenesulfonic acid monohydrate (0.45 g) in 100 mL of 3:1 THF/water is heated at reflux for 7 hours. The mixture is cooled and poured into sat. aq. NaHCO3, then extracted with ethyl acetate. The extract is dried over Na2SO4, filtered, and evaporated. The product is purified by chromatography on SiO2.

1. temperatureis heated
2. temperatureat reflux for 7 hours
3. temperatureThe mixture is cooled
4. extractionextracted with ethyl acetate
5. dry with materialThe extract is dried over Na2SO4
6. filtrationfiltered
7. customevaporated
8. customThe product is purified by chromatography on SiO2