Potassium Carbonate → HCID 18388574, compound

HRID 2296890Notes

Reaction equation

HRID 2296890 reaction equation
[NH:1]1[CH2:9][CH2:8][NH:7][CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.OC(C(F)(F)F)=O.Br[CH2:18][C:19]([NH2:21])=[O:20].C([O-])([O-])=O.[K+].[K+]>C(#N)C>[N:1]1([CH2:18][C:19]([NH2:21])=[O:20])[CH2:9][CH2:8][NH:7][CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 696322-BromoacetamideHCID 86585197HCID 86585197, compound

Product 1

HCID 18388574HCID 18388574, compoundYield 141.8%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Bis-TFA 1,4,7-triazacyclononane (261.4 mg, 0.81 mmol) was dissolved in acetonitrile (5.0 mL), bromoacetamide (168.1 mg, 1.22 mmol) and K2CO3 (225.0 mg, 1.62 mmol) were added sequentially. The mixture was refluxed for 15 hours. Filtration and chromatography of the residue after removal of all volatiles gave the desired product as an oil (214.0 mg, 70%).

Workup

  1. temperatureThe mixture was refluxed for 15 hours
  2. filtrationFiltration and chromatography of the residue
  3. customafter removal of all volatiles

Sources & evidence

ORD record
ord-6225828c98e741e7be9ce2ef4190ed29
Source dataset
uspto-grants-2002_12
Patent number
US06489472B2

Reaction notes

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