HRID2297054

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID9732

4-Fluorophenol

C6H5FO

HCID522689

Potassium fluoride

HCID21226206

未命名化合物

结构：CC(C)Cc1c(C(=O)N[C@H](C(=O)NC(CC(=O)OC(C)(C)C)C(=O)CBr)C(C)C)n(C)c2ccccc12

HCID86756359

未命名化合物

PRODUCTS

生成物

结构：CC(C)Cc1c(C(=O)N[C@H](C(=O)NC(CC(=O)OC(C)(C)C)C(=O)COc2ccc(F)cc2)C(C)C)n(C)c2ccccc12

HCID86756360

未命名化合物

收率 100%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

The titled product (72 mg, 100%) was prepared as a white solid as described in Example 82 using the product of Example 81 (68.0 mg, 0.12 mmol), potassium fluoride (15.6 mg, 0.27 mmol), and 4-fluorophenol (13.4 mg, 0.12 mmol) in DMF (2.0 ml) TLC (hexane/EtOAc, 50/50): Rf=0.48.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-94529e0aeb8b4961b8616742d674b5ca
来源数据集: uspto-grants-2002_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06489353B2
来源说明: uspto-grants-2002_12

反应 SMILES

[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([CH2:11][CH:12]([CH3:14])[CH3:13])=[C:3]1[C:15]([NH:17][C@H:18]([C:22]([NH:24][CH:25]([C:34](=[O:37])[CH2:35]Br)[CH2:26][C:27]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28])=[O:23])[CH:19]([CH3:21])[CH3:20])=[O:16].[F-].[K+].[F:40][C:41]1[CH:46]=[CH:45][C:44]([OH:47])=[CH:43][CH:42]=1.CCCCCC.CCOC(C)=O>CN(C=O)C>[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([CH2:11][CH:12]([CH3:14])[CH3:13])=[C:3]1[C:15]([NH:17][C@H:18]([C:22]([NH:24][CH:25]([C:34](=[O:37])[CH2:35][O:47][C:44]1[CH:45]=[CH:46][C:41]([F:40])=[CH:42][CH:43]=1)[CH2:26][C:27]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28])=[O:23])[CH:19]([CH3:21])[CH3:20])=[O:16]