HRID2297064

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7972

4-Methylmorpholine

C5H11NO

HCID15908

1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide

C8H17N3

HCID27695

1-Methyl-1H-indole-2-carboxylic acid

C10H9NO2

HCID75771

1-Hydroxybenzotriazole

C6H5N3O

结构：CC(C)[C@H](N)C(=O)C(C(=O)OC(C)(C)C)C(N)C(O)COc1c(F)c(F)cc(F)c1F

HCID131723667

未命名化合物

PRODUCTS

生成物

结构：CC(C)[C@H](NC(=O)c1cc2ccccc2n1C)C(=O)NC(CC(=O)OC(C)(C)C)C(O)COc1c(F)c(F)cc(F)c1F

HCID86756371

未命名化合物

收率 58.2%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

The procedure of Example 77 was followed using the product of Example 106 (197.0 mg, 0.44 mmol), 1-methylindole-2-carboxylic acid (152 mg, 0.87 mmol), NMM (0.047 ml, 0.44 mmol), HOBt (144 mg, 0.96 mmol), and EDAC (183 mg, 0.96 mmol) in methylene chloride to prepare the titled product (156 mg, 58%).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-7322b7ff3f7f41098a43edd75890883c
来源数据集: uspto-grants-2002_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06489353B2
来源说明: uspto-grants-2002_12

反应 SMILES

N[C@H](C([CH:8]([CH:16]([NH2:31])[CH:17]([OH:30])[CH2:18][O:19][C:20]1[C:25]([F:26])=[C:24]([F:27])[CH:23]=[C:22]([F:28])[C:21]=1[F:29])[C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])=O)C(C)C.[CH3:32][N:33]1[C:41]2[C:36](=[CH:37][CH:38]=[CH:39][CH:40]=2)[CH:35]=[C:34]1[C:42]([OH:44])=O.C[N:46]1[CH2:51][CH2:50][O:49]CC1.[CH:52]1[CH:53]=CC2N(O)N=NC=2[CH:57]=1.CCN=C=NCCCN(C)C>C(Cl)Cl>[CH3:32][N:33]1[C:41]2[C:36](=[CH:37][CH:38]=[CH:39][CH:40]=2)[CH:35]=[C:34]1[C:42]([NH:46][C@H:51]([C:50]([NH:31][CH:16]([CH:17]([OH:30])[CH2:18][O:19][C:20]1[C:21]([F:29])=[C:22]([F:28])[CH:23]=[C:24]([F:27])[C:25]=1[F:26])[CH2:8][C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])=[O:49])[CH:52]([CH3:53])[CH3:57])=[O:44]