1-(2,4-Dichlorophenyl)-2-morpholin-4-ylethan-1-one → (2e)-1-(2,4-Dichlorophenyl)-3-(dimethylamino)-2-morpholin-4-ylprop-2-en-1-one

HRID 2297132Notes

Reaction equation

HRID 2297132 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9](=[O:17])[CH2:10][N:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1>CN(C(OC)OC)C>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9](=[O:17])/[C:10](/[N:11]1[CH2:12][CH2:13][O:14][CH2:15][CH2:16]1)=[CH:10]\[N:11]([CH3:16])[CH3:12]

Participants

3

Reactant 1

HCID 221428751-(2,4-Dichlorophenyl)-2-morpholin-4-ylethan-1-one

Product 1

HCID 69308798(2e)-1-(2,4-Dichlorophenyl)-3-(dimethylamino)-2-morpholin-4-ylprop-2-en-1-one

Reagents, catalysts & solvents 1

HCID 78373Dimethylformamide dimethyl acetalSolvent

Procedure

1 mmol of 1-(2,4-dichlorophenyl)-2-morpholin-4-ylethan-1-one was heated to 80° C. in N,N-dimethylformamidedimethyl acetal for six hours. The reaction mixture was concentrated in vacuo and purified by trituration: with diethyl ether to obtain (2E)-1-(2,4-dichlorophenyl)-3-(dimethylamino)-2-morpholin-4-ylprop-2-en-1-one.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. custompurified by trituration

Sources & evidence

ORD record
ord-60d03fea7b2c45e39fe5a413034a728e
Source dataset
uspto-grants-2002_12
Patent number
US06489344B1

Reaction notes

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