Methylamine → 6-chloro-N-methyl-3-nitropyridin-2-amine

HRID 2297185Notes

Reaction equation

HRID 2297185 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([N:8](C)[CH3:9])[C:5]([N+:11]([O-:13])=[O:12])=[CH:4][CH:3]=1.CN>>[Cl:1][C:2]1[N:7]=[C:6]([NH:8][CH3:9])[C:5]([N+:11]([O-:13])=[O:12])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 217876256-Chloro-2-dimethylamino-3-nitropyridine

Product 1

HCID 107500946-chloro-N-methyl-3-nitropyridin-2-amine

Procedure

6-chloro-2-methylamino-3-nitro-pyridine was prepared in accordance to the procedure described above for the preparation of 6-chloro-2-dimethylamino-3-nitro pyridine by using solution of methyl amine. The crude product was purified by flash chromatography, eluting with 90% hexane: 10% ethyl acetate to 16 (300 mg).

Workup

  1. customThe crude product was purified by flash chromatography
  2. washeluting with 90% hexane

Sources & evidence

ORD record
ord-007012c06bae43de971176a8f4bd75bb
Source dataset
uspto-grants-2002_12
Patent number
US06489344B1

Reaction notes

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