反应详情

To an acetone solution (5 mL) of 7-methyl-3-(3-trifluoromethylphenyl)cinnolin-5-ol (69 mg, 0.2 mmol) obtained in Example 70 were added benzyl bromide (0.024 mL) and potassium carbonate (28 mg, 0.2 mmol), followed by stirring at room temperature over night and refluxing under heating for 3 hours. The reaction liquid was further added with benzyl bromide (0.024 mL) and potassium carbonate (28 mg, 0.2 mmol), followed by stirring at room temperature over night, concentration of the reaction liquid under reduced pressure, adding distilled water (1 mL), extraction with ethyl acetate and purification of residue obtained after concentration of an organic layer under reduced pressure, with HPLC column chromatography (hexane/ethyl acetate=3/1) to obtain an objective compound (8 mg, 10%).

1. temperaturerefluxing
2. temperatureunder heating for 3 hours
3. customThe reaction liquid
4. stirringby stirring at room temperature over night
5. customconcentration of the reaction liquid under reduced pressure
6. additionadding
7. distillationdistilled
8. extractionwater (1 mL), extraction
9. customwith ethyl acetate and purification of residue
10. customobtained after concentration of an organic layer under reduced pressure