Hydroxylamine → HCID 86588181, compound

HRID 2297673Notes

Reaction equation

HRID 2297673 reaction equation
[CH3:1][O:2][C@H:3]1[C@@H:7]2[O:8][C:9]([CH3:12])([CH3:11])[O:10][C@@H:6]2[C@@H:5]([C:13]#[C:14][C:15](=[O:18])[CH2:16][CH3:17])[O:4]1.[NH2:19][OH:20]>C(O)C>[CH3:1][O:2][C@H:3]1[C@@H:7]2[O:8][C:9]([CH3:12])([CH3:11])[O:10][C@@H:6]2[C@@H:5]([C:13](=[N:19][OH:20])[CH2:14][C:15](=[O:18])[CH2:16][CH3:17])[O:4]1

Participants

4

Reactant 2

HCID 787HydroxylamineHCID 69827849HCID 69827849, compound

Product 1

HCID 86588181HCID 86588181, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
22 °C

Procedure

A mixture of 1-[(3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl]pent-1-yn-3-one (550 mg) and hydroxylamine (50% solution in water) (0.2 ml) in ethanol (10 ml) was stirred overnight at 22° C. The mixture was concentrated in vacuo to afford the title compound as a yellow oil (554 mg).

Workup

  1. concentrationThe mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-db5b6b9db0bf4d5e830eb2e26e99a472
Source dataset
uspto-grants-2002_12
Patent number
US06492348B1

Reaction notes

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