Tert-Butylamine → HCID 86588189, compound

HRID 2297688Notes

Reaction equation

HRID 2297688 reaction equation
C([O:4][C@@H:5]1[C@H:9]([O:10]C(=O)C)[C@@H:8]([C:14]2[O:18][N:17]=[C:16]([CH2:19][O:20]C(=O)C)[CH:15]=2)[O:7][C@H:6]1[N:24]1[CH:32]=[N:31][C:30]2[C:25]1=[N:26][C:27]([Cl:42])=[N:28][C:29]=2[NH:33][C:34]1[CH:39]=[CH:38][C:37]([Cl:40])=[CH:36][C:35]=1[F:41])(=O)C.C(N)(C)(C)C>CO>[Cl:42][C:27]1[N:26]=[C:25]2[C:30]([N:31]=[CH:32][N:24]2[C@H:6]2[C@H:5]([OH:4])[C@H:9]([OH:10])[C@@H:8]([C:14]3[O:18][N:17]=[C:16]([CH2:19][OH:20])[CH:15]=3)[O:7]2)=[C:29]([NH:33][C:34]2[CH:39]=[CH:38][C:37]([Cl:40])=[CH:36][C:35]=2[F:41])[N:28]=1

Participants

4

Reactant 2

HCID 6385Tert-ButylamineHCID 18336823HCID 18336823, compound

Product 1

HCID 86588189HCID 86588189, compoundYield 77.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To (2R,3R,4R,5S)-4-(acetyloxy)-5-{3-[(acetyloxy)methyl]isoxazol-5-yl}-2-[2-chloro-6-(4-chloro-2-fluoroanilino)-9H-purin-9-yl]tetrahydrofuran-3-yl acetate (4.02 mg) in methanol (2 ml) at 0° C. was added tert-butylamine (0.012 ml), and the mixture was allowed to stand at 0 ° C. for 3 h. The solvent was evaporated in vacuo to furnish the title compound as a yellow gum (2.48 mg).

Workup

  1. customThe solvent was evaporated in vacuo

Sources & evidence

ORD record
ord-91b0f30812b649cbab5b97f195b84673
Source dataset
uspto-grants-2002_12
Patent number
US06492348B1

Reaction notes

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