Hydrogen Peroxide → HCID 18383971, compound

HRID 2297691Notes

Reaction equation

HRID 2297691 reaction equation
[Cl:1][CH2:2][C:3]([C:5]1[CH:9]=[C:8]([C:10](=[O:20])[C:11]2[CH:16]=[CH:15][C:14]([S:17]([CH3:19])=[O:18])=[CH:13][CH:12]=2)[N:7]([CH3:21])[CH:6]=1)=[O:4].[OH:22]O>CC(O)=O>[Cl:1][CH2:2][C:3]([C:5]1[CH:9]=[C:8]([C:10](=[O:20])[C:11]2[CH:16]=[CH:15][C:14]([S:17]([CH3:19])(=[O:22])=[O:18])=[CH:13][CH:12]=2)[N:7]([CH3:21])[CH:6]=1)=[O:4]

Participants

4

Reactant 2

HCID 784Hydrogen PeroxideHCID 18383974HCID 18383974, compound

Product 1

HCID 18383971HCID 18383971, compoundYield 30%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of 2.5 g (0.0074 mole) of 2-chloro-1-[1-methyl-5-(4-(methylsulfinyl)benzoyl]-1H-pyrrol-3-yl]-ethanone, 20 mL of HOAc, and 1.7 mL of 30% H2O2 was stirred for 6 days. The solid was filtered off to give 0.75 g (30%) of 2-chloro-1-[1-methyl-5-(4-(methylsulfonyl)benzoyl]-1H-pyrrol-3-yl]-ethanone. HNMR (CDCl3) δ8.1 (s, 2H); 8.0 (s, 2H); 7.7 (ar, 1H); 7.1 (ar, 1H); 4.4 (s, 2H); 4.1 (s, 3H); 3.1 (s, 3H).

Workup

  1. filtrationThe solid was filtered off

Sources & evidence

ORD record
ord-b6dcf4e6b1444eef926fca4a1701ea0a
Source dataset
uspto-grants-2002_12
Patent number
US06492387B2

Reaction notes

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