反应详情

温度

120 °C

To a stirred mixture of 4-amino-1-naphthol hydrochloride (2.5 g, 12.8 mmol) and 4-chloropyridine hydrochloride (3.84 g, 29.2 mmol) in NMP (20 ml) was added potassium tert-butoxide (6.0 g, 53.47 mmol) slowly. The mixture was heated at 120° C. for 6 h, cooled to room temperature and diluted with water and dichloromethane. The combined organic extracts were washed with HCl (2N), saturated aqueous NaHCO3 and brine and dried (Na2SO4). Removal of the volatiles in vacuo afforded the product (0.5 g, 16%).

1. temperaturecooled to room temperature
2. washThe combined organic extracts were washed with HCl (2N), saturated aqueous NaHCO3 and brine
3. dry with materialdried (Na2SO4)
4. customRemoval of the volatiles in vacuo