Hydrochloric Acid → HCID 18382944, compound

HRID 2297777Notes

Reaction equation

HRID 2297777 reaction equation
[OH:1][CH2:2][CH2:3][NH:4][CH2:5][CH2:6][OH:7].[NH:8]1[C:16]2[C:11](=[CH:12][C:13]([NH:17][C:18]3[C:19]4[S:26][C:25]([C:27]5[CH:34]=[CH:33][C:30]([CH:31]=O)=[CH:29][CH:28]=5)=[CH:24][C:20]=4[N:21]=[CH:22][N:23]=3)=[CH:14][CH:15]=2)[CH:10]=[CH:9]1.Cl>>[OH:1][CH2:2][CH2:3][N:4]([CH2:31][C:30]1[CH:29]=[CH:28][C:27]([C:25]2[S:26][C:19]3[C:18]([NH:17][C:13]4[CH:12]=[C:11]5[C:16](=[CH:15][CH:14]=4)[NH:8][CH:9]=[CH:10]5)=[N:23][CH:22]=[N:21][C:20]=3[CH:24]=2)=[CH:34][CH:33]=1)[CH2:5][CH2:6][OH:7]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 8113DiethanolamineHCID 183827594-(4-(1H-indol-5-ylamino)-thieno[3,2-d]pyrimidin-6-yl]-benzaldehyde

Product 1

HCID 18382944HCID 18382944, compound

Procedure

The title compound was prepared from 2-(2-hydroxy-ethylamino)-ethanol and 4-[4-(1H-indol-5-ylamino)-thieno[3,2-d]pyrimidin-6-yl]-benzaldehyde by a procedure analogous to example 17. The product was converted to the mesylate salt analogous to example 17 being converted to the HCl salt. M.P. 110-127° C.; LC-MS: 460 (MH+); HPLC RT: 3.50 minutes.

Sources & evidence

ORD record
ord-1450f6e608bd4e298c73a0cfbf0bf66b
Source dataset
uspto-grants-2002_12
Patent number
US06492383B1

Reaction notes

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