Aminoethylpiperazine → (1H-Indol-5-yl)-(2-{4-[(2-piperazin-1-yl-ethylamino)-methyl]-phenyl}-thieno[3,2-b]pyridine-7-yl)-amine

HRID 2297805Notes

Reaction equation

HRID 2297805 reaction equation
[N:1]1([CH2:7][CH2:8][NH2:9])[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[NH:10]1[C:18]2[C:13](=[CH:14][C:15]([NH:19][C:20]3[CH:25]=[CH:24][N:23]=[C:22]4[CH:26]=[C:27]([C:29]5[CH:36]=[CH:35][C:32]([CH:33]=O)=[CH:31][CH:30]=5)[S:28][C:21]=34)=[CH:16][CH:17]=2)[CH:12]=[CH:11]1>>[NH:10]1[C:18]2[C:13](=[CH:14][C:15]([NH:19][C:20]3[CH:25]=[CH:24][N:23]=[C:22]4[CH:26]=[C:27]([C:29]5[CH:36]=[CH:35][C:32]([CH2:33][NH:9][CH2:8][CH2:7][N:1]6[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]6)=[CH:31][CH:30]=5)[S:28][C:21]=34)=[CH:16][CH:17]=2)[CH:12]=[CH:11]1

Participants

3

Reactant 2

HCID 8795AminoethylpiperazineHCID 183827434-[7-(1H-Indol-5-ylamino)-thieno[3,2-b]pyridin-2-yl]-benzaldehyde

Product 1

HCID 18382875(1H-Indol-5-yl)-(2-{4-[(2-piperazin-1-yl-ethylamino)-methyl]-phenyl}-thieno[3,2-b]pyridine-7-yl)-amine

Procedure

The title compound was prepared from 2-piperazin-1-yl-ethylamine and 4-[7-(1H-indol-5-ylamino)-thieno(3,2-b]pyridin-2-yl]-benzaldehyde by a procedure analogous to example 17. LC-MS: 483 (MH+); HPLC RT: 3.41 minutes.

Sources & evidence

ORD record
ord-e005a29f9be44d8fa6eec657cb8115f3
Source dataset
uspto-grants-2002_12
Patent number
US06492383B1

Reaction notes

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