反应详情

温度

90 °C

In a sealed tube (2-bromo-thieno[3,2-b]pyridin-7-yl)-(1H-indol-5-yl)-amine (150 mg, 0.29 mmol) and 2-(tributylstannyl)pyridine (118 mg, 1.1 mmol) were combined in 3 mL of dimethylformamide along with copper iodide (3 mg, 0.015 mmol). Nitrogen was bubbled through the solution and trans-benzyl(chloro)bis-(triphenylphosphine)palladium(II) (33 mg, 0.044 mmol) was added, the tube was sealed and heated to 90° C. After 14 hours the solution was cooled and concentrated to dryness. Chromatography on 15 g of silica gel with CH2Cl2/MeOH (5-20%) afforded 30.3 mg (28%) of,the title compound. LC-MS: 343 (MH+); HPLC RT: 3.94 minutes.

1. additionwas added
2. customthe tube was sealed
3. temperatureAfter 14 hours the solution was cooled
4. concentrationconcentrated to dryness