Ethyl Acetate → HCID 22351209, compound

HRID 2297929Notes

Reaction equation

HRID 2297929 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)=[CH:4][CH:3]=1.[CH2:15]([O:22][C:23]([NH:25][CH:26]([CH:34]1[O:36][CH2:35]1)[CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)=[O:24])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.CCOC(C)=O>CN(C=O)C>[CH2:15]([O:22][C:23]([NH:25][CH:26]([CH:34]([OH:36])[CH2:35][N:12]1[CH2:11][CH2:10][CH:9]([CH2:8][C:5]2[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=2)[CH2:14][CH2:13]1)[CH2:27][C:28]1[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=1)=[O:24])[C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1

Participants

5

Reactant 3

HCID 8857Ethyl AcetateHCID 36998414-(4-Fluoro-benzyl)-piperidineHCID 148872432-Benzyloxycarbonylamino-1-phenyl-3,4-epoxy-butane

Product 1

HCID 22351209HCID 22351209, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of 4- (4-fluorophenyl)methyl-piperidine (0.515 g, 2.314 mmoles) and 2-benzyloxycarbonylamino-1-phenyl-3,4-epoxy-butane (0.688 g, 2.314 mmoles) in 5 mL of DMF was stirred for 4 hours at 100° C. and cooled to room temperature. After addition of EtOAc (30 mL), the mixture was washed with water (2×) and brine. The oranic solution was dried over Na2SO4, and evaporated to give an oily residue. It was then purified by passing through a plug of silica gel with elution by EtOAc to give pure product.

Workup

  1. washthe mixture was washed with water (2×) and brine
  2. dry with materialThe oranic solution was dried over Na2SO4
  3. customevaporated
  4. customto give an oily residue
  5. customIt was then purified
  6. washwith elution by EtOAc
  7. customto give pure product

Sources & evidence

ORD record
ord-c052e4b4750745c7a9eb06d4c7d61092
Source dataset
uspto-grants-2002_12
Patent number
US06492400B1

Reaction notes

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