Tricyclo(3.3.1.13,7)dec-1-ylmethylamine → HCID 57244288, compound

HRID 2298048Notes

Reaction equation

HRID 2298048 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][C:8]([N:11]2[CH2:16][CH2:15][CH:14]([NH:17][C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])[CH2:13][CH2:12]2)=[CH:7][C:3]=1[C:4](O)=[O:5].[C:25]12([CH2:35][NH2:36])[CH2:34][CH:29]3[CH2:30][CH:31]([CH2:33][CH:27]([CH2:28]3)[CH2:26]1)[CH2:32]2>CN(C)C=O>[Cl:1][C:2]1[CH:10]=[CH:9][C:8]([N:11]2[CH2:12][CH2:13][CH:14]([NH:17][C:18](=[O:19])[O:20][C:21]([CH3:22])([CH3:24])[CH3:23])[CH2:15][CH2:16]2)=[CH:7][C:3]=1[C:4]([NH:36][CH2:35][C:25]12[CH2:34][CH:29]3[CH2:28][CH:27]([CH2:33][CH:31]([CH2:30]3)[CH2:32]1)[CH2:26]2)=[O:5]

Participants

4

Reactant 2

HCID 86625Tricyclo(3.3.1.13,7)dec-1-ylmethylamineHCID 18381485HCID 18381485, compound

Product 1

HCID 57244288HCID 57244288, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Prepared as described in Example 5c) using 2-chloro-5-[4-[[(1,1-dimethylethoxy)carbonyl]amino]-1-piperidinyl]-benzoic acid (Example 6b, 0.065 g), N,N′-carbonyldiimidazole (0.030 g), 1-adamantanemethylamine (0.032 ml) and dimethylformamide (3 ml) to give the subtitle compound as a solid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-2db6b50840344e5c8f15fe2ba3f58572
Source dataset
uspto-grants-2002_12
Patent number
US06492355B1

Reaction notes

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