Tricyclo(3.3.1.13,7)dec-1-ylmethylamine → HCID 57037521, compound

HRID 2298052Notes

Reaction equation

HRID 2298052 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][C:8]([N:11]2[CH2:15][CH2:14][CH:13]([NH:16][C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:12]2)=[CH:7][C:3]=1[C:4]([OH:6])=O.[C:24]12([CH2:34][NH2:35])[CH2:33][CH:28]3[CH2:29][CH:30]([CH2:32][CH:26]([CH2:27]3)[CH2:25]1)[CH2:31]2>CN(C)C=O>[Cl:1][C:2]1[CH:10]=[CH:9][C:8]([N:11]2[CH2:15][CH2:14][CH:13]([NH:16][C:17](=[O:18])[O:19][C:20]([CH3:23])([CH3:22])[CH3:21])[CH2:12]2)=[CH:7][C:3]=1[C:4]([NH:35][CH2:34][C:24]12[CH2:33][CH:28]3[CH2:27][CH:26]([CH2:32][CH:30]([CH2:29]3)[CH2:31]1)[CH2:25]2)=[O:6]

Participants

4

Reactant 2

HCID 86625Tricyclo(3.3.1.13,7)dec-1-ylmethylamineHCID 53742797HCID 53742797, compound

Product 1

HCID 57037521HCID 57037521, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Prepared as described in Example 5c) using (+/−)-2-chloro-5-[3-[[(1,1-dimethylethoxy)carbonyl]amino]-1-pyrrolidinyl]-benzoic acid (Example 7b, 0.070 g), N,N′-carbonyldiimidazole (0.033 g), 1-adamantanemethylamine (0.036 ml) and dimethylformamide (3 ml) to give the subtitle compound as a gum.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-a38a354068ad40f08a0a06fefebc0067
Source dataset
uspto-grants-2002_12
Patent number
US06492355B1

Reaction notes

Loading…