Hydrochloric Acid → HCID 9845234, compound

HRID 2298053Notes

Reaction equation

HRID 2298053 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:12][CH2:11][CH:10]([NH:13]C(=O)OC(C)(C)C)[CH2:9]2)=[CH:4][C:3]=1[C:21]([NH:23][CH2:24][C:25]12[CH2:34][CH:29]3[CH2:30][CH:31]([CH2:33][CH:27]([CH2:28]3)[CH2:26]1)[CH2:32]2)=[O:22].Cl.CO>O1CCOCC1>[ClH:1].[NH2:13][CH:10]1[CH2:11][CH2:12][N:8]([C:5]2[CH:6]=[CH:7][C:2]([Cl:1])=[C:3]([CH:4]=2)[C:21]([NH:23][CH2:24][C:25]23[CH2:26][CH:27]4[CH2:28][CH:29]([CH2:30][CH:31]([CH2:33]4)[CH2:32]2)[CH2:34]3)=[O:22])[CH2:9]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 57037521HCID 57037521, compound

Product 1

HCID 9845234HCID 9845234, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Prepared as described in example 5d) above using (+/−)-[1-[4-chloro-3-[[(tricyclo[3.3.1.13,7]dec-1-ylmethyl)amino]carbonyl]phenyl]-3-pyrrolidinyl]-carbamic acid, 1,1-dimethylethyl ester (Example 7c), hydrochloric acid (0.5 ml of a 4N solution in dioxane) and methanol (5 ml). Evaporation under reduced pressure gave a solid on trirtuation with diethyl ether. Recrystallisation from methanol/diethyl ether gave the title compound as a solid (0.030 g).

Workup

  1. customPrepared
  2. customEvaporation under reduced pressure
  3. customgave a solid on trirtuation with diethyl ether
  4. customRecrystallisation from methanol/diethyl ether

Sources & evidence

ORD record
ord-7f802bfb4ade4159b7790c4dfd33ef7a
Source dataset
uspto-grants-2002_12
Patent number
US06492355B1

Reaction notes

Loading…