Dimethylformamide → HCID 54030420, compound

HRID 2298234Notes

Reaction equation

HRID 2298234 reaction equation
[I:1][C:2]1[CH:10]=[C:6]([C:7](O)=[O:8])[C:5]([OH:11])=[CH:4][CH:3]=1.O=S(Cl)[Cl:14].CN(C=O)C>C1(C)C=CC=CC=1>[I:1][C:2]1[CH:10]=[C:6]([C:7]([Cl:14])=[O:8])[C:5]([OH:11])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 6228DimethylformamideHCID 83885-Iodosalicylic acidHCID 24386Thionyl Chloride

Product 1

HCID 54030420HCID 54030420, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

5-Iodosalicylic acid (2.0 g, 7.58 mmol) in toluene was treated with SOCl2 (1.66 mL, 22.7 mmol) and catalytic DMF at reflux for 1 h. The reaction mixture was evaporated to dryness and the acid chloride used in the next step without purification.

Workup

  1. temperatureat reflux for 1 h
  2. customThe reaction mixture was evaporated to dryness
  3. customthe acid chloride used in the next step without purification

Sources & evidence

ORD record
ord-437be27a1cb44413a30fc9ae62112a26
Source dataset
uspto-grants-2002_12
Patent number
US06492425B1

Reaction notes

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