Methanesulfonyl chloride → HCID 18385233, compound

HRID 2298244Notes

Reaction equation

HRID 2298244 reaction equation
[CH3:1][S:2](Cl)(=[O:4])=[O:3].[CH2:6]([N:13]1[CH2:18][CH2:17][CH:16]([CH2:19][OH:20])[CH2:15][CH2:14]1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.C(N(CC)C(C)C)(C)C>ClCCl.COC(C)(C)C>[CH3:1][S:2]([O-:4])(=[O:20])=[O:3].[CH2:6]([N+:13]12[CH2:19][CH:16]([CH2:17][CH2:18]1)[CH2:15][CH2:14]2)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

Participants

6

Reactant 3

HCID 31297Methanesulfonyl chlorideHCID 81531DiisopropylethylamineHCID 736802(1-Benzylpiperidin-4-yl)methanol

Product 1

HCID 18385233HCID 18385233, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolvent2×HCID 15413tert-Butyl methyl etherSolvent

Procedure

Methanesulfonyl chloride (0.22 mL, 2.85 mmole) in dichloromethane (2 mL) was added dropwise to a ice-cooled solution of N-benzyl-4-hydroxymethyl-piperidine (531 mg, 2.59 mmol) and N,N-diisopropylethylamine (0.66 mL, 3.88 mmol) in dichloromethane (3 mL). The mixture was stirred for 5 min, diluted with tert-butyl methyl ether, washed with water and brine. The solvents were removed to give the sub-title compound.

Workup

  1. washwashed with water and brine
  2. customThe solvents were removed

Sources & evidence

ORD record
ord-8b6759dd811043febe67d9f420a36255
Source dataset
uspto-grants-2002_12
Patent number
US06492406B1

Reaction notes

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