Sodium Iodide → HCID 70054803, compound

HRID 2298252Notes

Reaction equation

HRID 2298252 reaction equation
[CH3:1][O:2][C:3](=[O:31])[C@H:4]([CH2:23][C:24]1[CH:29]=[CH:28][C:27]([OH:30])=[CH:26][CH:25]=1)[NH:5][C:6](=[O:22])[C@@H:7]1[CH2:11][CH2:10][CH2:9][N:8]1[S:12]([C:15]1[CH:20]=[CH:19][C:18]([CH3:21])=[CH:17][CH:16]=1)(=[O:14])=[O:13].C(=O)([O-])[O-].[K+].[K+].[I-].[Na+].[CH3:40][C:41](=O)[CH2:42][CH3:43]>>[CH3:1][O:2][C:3](=[O:31])[C@H:4]([CH2:23][C:24]1[CH:29]=[CH:28][C:27]([O:30][CH2:24][CH2:23][CH2:4][N:5]([CH3:6])[CH2:40][C:41]2[CH:11]=[CH:10][CH:9]=[CH:43][CH:42]=2)=[CH:26][CH:25]=1)[NH:5][C:6](=[O:22])[C@@H:7]1[CH2:11][CH2:10][CH2:9][N:8]1[S:12]([C:15]1[CH:20]=[CH:19][C:18]([CH3:21])=[CH:17][CH:16]=1)(=[O:13])=[O:14]

Participants

5

Reactant 4

HCID 5238Sodium IodideHCID 6569Methyl Ethyl KetoneHCID 11430Potassium CarbonateHCID 54334627HCID 54334627, compound

Product 1

HCID 70054803HCID 70054803, compound

Procedure

The title compound was prepared via O-alkylation of N-(toluene-4-sulfonyl)-L-prolyl-L-tyrosine methyl ester with 3-(N-benzyl,N-methyl)aminopropyl chloride in refluxing 2-butanone in the presence of potassium carbonate and sodium iodide to provide a solid, mp=60-70° C.

Workup

  1. customto provide a solid, mp=60-70° C.

Sources & evidence

ORD record
ord-19585577891046c3afd957d18f6de65e
Source dataset
uspto-grants-2002_12
Patent number
US06492421B1

Reaction notes

Loading…