Sodium Iodide → HCID 70053901, compound

HRID 2298259Notes

Reaction equation

HRID 2298259 reaction equation
[CH3:1][O:2][C:3](=[O:31])[C@H:4]([CH2:23][C:24]1[CH:29]=[CH:28][C:27]([OH:30])=[CH:26][CH:25]=1)[NH:5][C:6](=[O:22])[C@@H:7]1[CH2:11][CH2:10][CH2:9][N:8]1[S:12]([C:15]1[CH:20]=[CH:19][C:18]([CH3:21])=[CH:17][CH:16]=1)(=[O:14])=[O:13].[N:32](=[CH:40][CH2:41]Cl)[CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38]Cl.C(=O)([O-])[O-].[K+].[K+].[I-].[Na+]>CC(=O)CC>[CH3:1][O:2][C:3](=[O:31])[C@H:4]([CH2:23][C:24]1[CH:29]=[CH:28][C:27]([O:30][CH2:41][CH2:40][N:32]2[CH2:38][CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]2)=[CH:26][CH:25]=1)[NH:5][C:6](=[O:22])[C@@H:7]1[CH2:11][CH2:10][CH2:9][N:8]1[S:12]([C:15]1[CH:20]=[CH:19][C:18]([CH3:21])=[CH:17][CH:16]=1)(=[O:13])=[O:14]

Participants

6

Reactant 4

HCID 5238Sodium IodideHCID 11430Potassium CarbonateHCID 534452782-(Hexamethyleneimino)ethyl chlorideHCID 54334627HCID 54334627, compound

Product 1

HCID 70053901HCID 70053901, compound

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

The title compound was prepared via O-alkylation of N-(toluene-4-sulfonyl)-L-prolyl-L-tyrosine methyl ester with 2-(hexamethylene-imino)ethyl chloride in refluxing 2-butanone in the presence of potassium carbonate and sodium iodide to provide a solid, mp=60-65° C.

Workup

  1. customto provide a solid, mp=60-65° C.

Sources & evidence

ORD record
ord-573b7988537b4bd69f35a2bbca7021ac
Source dataset
uspto-grants-2002_12
Patent number
US06492421B1

Reaction notes

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