Acetone → HCID 178433913, compound

HRID 2298695Notes

Reaction equation

HRID 2298695 reaction equation
[OH:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][C:10]([S:13]([OH:16])(=[O:15])=[O:14])=[CH:9][CH:8]=2)[N:5]=[C:4]([CH3:17])[CH:3]=1.[NH:18]1[C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[C:20]([CH:27]=O)=[CH:19]1.[CH2:29]([N:31]([CH2:34][CH3:35])[CH2:32][CH3:33])[CH3:30].CC(C)=O>C(O)C>[NH:18]1[C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[C:20]([CH:27]=[C:3]2[C:2](=[O:1])[N:6]([C:7]3[CH:8]=[CH:9][C:10]([S:13]([O-:16])(=[O:15])=[O:14])=[CH:11][CH:12]=3)[N:5]=[C:4]2[CH3:17])=[CH:19]1.[CH2:29]([NH+:31]([CH2:34][CH3:35])[CH2:32][CH3:33])[CH3:30]

Participants

6

Reactant 4

HCID 180AcetoneHCID 8471TriethylamineHCID 10256Indole-3-CarboxaldehydeHCID 178429269HCID 178429269, compound

Product 1

HCID 178433913HCID 178433913, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2.55 g of 5-hydroxy-3-methyl-1-(4-sulfophenyl)-1H-pyrazole, 1.45 g of indole-3-carboxaldehyde and 1.05 g of triethylamine in 25 mL of ethanol were heated at 60° C. After 12 hours, the mixture was cooled, acetone was added dropwise so as to induce crystallization, and the mixture was then filtered.

Workup

  1. temperaturethe mixture was cooled
  2. customcrystallization
  3. filtrationthe mixture was then filtered

Sources & evidence

ORD record
ord-e951cbca74d64d4f9253979b85d145eb
Source dataset
uspto-grants-2002_12
Patent number
US06494923B2

Reaction notes

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