Hydrogen Peroxide → HCID 18378545, compound

HRID 2298820Notes

Reaction equation

HRID 2298820 reaction equation
[CH3:1][O:2][C:3]1[CH:21]=[C:20]([C:22]([N:24]2[C:30]3[CH:31]=[CH:32][CH:33]=[CH:34][C:29]=3[S:28][CH2:27][CH2:26][CH2:25]2)=[O:23])[CH:19]=[CH:18][C:4]=1[C:5]([NH:7][C:8]1[C:16]2[N:15]=[C:14]([CH3:17])[NH:13][C:12]=2[CH:11]=[CH:10][CH:9]=1)=[O:6].OO.C([O-])(O)=[O:38].[Na+]>CC(O)=O>[CH3:1][O:2][C:3]1[CH:21]=[C:20]([C:22]([N:24]2[C:30]3[CH:31]=[CH:32][CH:33]=[CH:34][C:29]=3[S:28](=[O:38])[CH2:27][CH2:26][CH2:25]2)=[O:23])[CH:19]=[CH:18][C:4]=1[C:5]([NH:7][C:8]1[C:16]2[N:15]=[C:14]([CH3:17])[NH:13][C:12]=2[CH:11]=[CH:10][CH:9]=1)=[O:6]

Participants

5

Reactant 3

HCID 784Hydrogen PeroxideHCID 516892Sodium BicarbonateHCID 9869415HCID 9869415, compound

Product 1

HCID 18378545HCID 18378545, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

To a solution of 2-methoxy-N-(2-methyl-1H-benzimidazol-4-yl)-4-(2,3,4,5-tetrahydro-1,5-benzothiazepin-5-yl)carbonylbenzamide (20 mg) in AcOH (1 ml), was added 30% aqueous H2O2 (1 ml), and the mixture was stirred for 4 hours. Saturated aqueous NaHCO3 was added to the reaction mixture, and the mixture was extracted with AcOEt, washed with brine and dried over Na2CO3. The solvent was removed under reduced pressure to give 2-methoxy-N-(2-methyl-1H-benzimidazol-4-yl)-4-(1-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-5-yl)carbonylbenzamide (20 mg).

Workup

  1. extractionthe mixture was extracted with AcOEt
  2. washwashed with brine
  3. dry with materialdried over Na2CO3
  4. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-c1adbfd9ea2e44b4bd87185eeb67d5e2
Source dataset
uspto-grants-2002_12
Patent number
US06495542B1

Reaction notes

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