Dimethylformamide → HCID 15432463, compound

HRID 2298870Notes

Reaction equation

HRID 2298870 reaction equation
CN(C=O)C.C(Cl)(=O)C(Cl)=O.[Cl:12][C:13]1[CH:14]=[C:15]([CH:36]=[CH:37][C:38]=1[O:39][CH3:40])[CH2:16][NH:17][C:18]1[C:19]2[C:31]3[CH2:32][CH2:33][CH2:34][CH2:35][C:30]=3[S:29][C:20]=2[N:21]=[C:22]([CH2:24][CH2:25][C:26]([NH2:28])=O)[N:23]=1>C(#N)C>[Cl:12][C:13]1[CH:14]=[C:15]([CH:36]=[CH:37][C:38]=1[O:39][CH3:40])[CH2:16][NH:17][C:18]1[C:19]2[C:31]3[CH2:32][CH2:33][CH2:34][CH2:35][C:30]=3[S:29][C:20]=2[N:21]=[C:22]([CH2:24][CH2:25][C:26]#[N:28])[N:23]=1

Participants

5

Reactant 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 15432462HCID 15432462, compound

Product 1

HCID 15432463HCID 15432463, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

1 equivalent of DMF and 1 equivalent of oxalyl chloride are dissolved in acetonitrile at 0°. 1 equivalent of 3-[4-(3-chloro-4-methoxybenzylamino)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine-2-yl]propionamide is then added. The mixture is stirred for one hour. After customary working up, 3-[4-(3-chloro-4-methoxybenzylamino)-5,6,7,8-tetrahydro[1]-benzothieno[2,3-d]pyrimidine-2-yl]propionitrile is obtained.

Sources & evidence

ORD record
ord-ea973fad53b14af18152b79be17fadb2
Source dataset
uspto-grants-2002_12
Patent number
US06495554B2

Reaction notes

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