Potassium Carbonate → 4-Chloro-N-{1-[(3,4-dioxo-2-{[5-(trifluoromethyl)pyridin-3-yl]amino}-1-cyclobuten-1-yl)amino]-2,2-dimethyl-3-phenylpropyl}benzamide

HRID 2299079Notes

Reaction equation

HRID 2299079 reaction equation
[NH2:1][C:2]1[C:3](=[O:18])[C:4](=[O:17])[C:5]=1[NH:6][C:7]1[CH:8]=[N:9][CH:10]=[C:11]([C:13]([F:16])([F:15])[F:14])[CH:12]=1.N1([CH:28]([NH:39][C:40](=[O:48])[C:41]2[CH:46]=[CH:45][C:44]([Cl:47])=[CH:43][CH:42]=2)[C:29]([CH3:38])([CH3:37])[CH2:30][C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)C2C=CC=CC=2N=N1.C([O-])([O-])=O.[K+].[K+]>>[Cl:47][C:44]1[CH:45]=[CH:46][C:41]([C:40]([NH:39][CH:28]([NH:1][C:2]2[C:3](=[O:18])[C:4](=[O:17])[C:5]=2[NH:6][C:7]2[CH:8]=[N:9][CH:10]=[C:11]([C:13]([F:15])([F:16])[F:14])[CH:12]=2)[C:29]([CH3:37])([CH3:38])[CH2:30][C:31]2[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=2)=[O:48])=[CH:42][CH:43]=1

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 183796773-Amino4-(5-trifluoromethyl-3-pyridinylamino)cyclobut-3-ene-1,2-dioneHCID 18770575N-[1-(1H-1,2,3-benzotriazol-1-yl)-2,2-dimethyl-3-phenylpropyl]-4-chlorobenzamide

Product 1

HCID 101441854-Chloro-N-{1-[(3,4-dioxo-2-{[5-(trifluoromethyl)pyridin-3-yl]amino}-1-cyclobuten-1-yl)amino]-2,2-dimethyl-3-phenylpropyl}benzamide

Procedure

A suspension of the product from Example 52C, the product from Example 18B, and K2CO3 was processed as described in Example 1D to provide the title compound.

Sources & evidence

ORD record
ord-7ae9c7f8b0f34f11beca5cbac5950a7c
Source dataset
uspto-grants-2002_12
Patent number
US06495576B2

Reaction notes

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