HRID2299079

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11430

Potassium Carbonate

CK2O3

HCID18379677

未命名化合物

结构：CC(C)(Cc1ccccc1)C(NC(=O)c1ccc(Cl)cc1)n1nnc2ccccc21

HCID18770575

未命名化合物

PRODUCTS

生成物

结构：CC(C)(Cc1ccccc1)C(NC(=O)c1ccc(Cl)cc1)Nc1c(Nc2cncc(C(F)(F)F)c2)c(=O)c1=O

HCID10144185

未命名化合物

PROCEDURE

实验过程

A suspension of the product from Example 52C, the product from Example 18B, and K2CO3 was processed as described in Example 1D to provide the title compound.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-7ae9c7f8b0f34f11beca5cbac5950a7c
来源数据集: uspto-grants-2002_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06495576B2
来源说明: uspto-grants-2002_12

反应 SMILES

[NH2:1][C:2]1[C:3](=[O:18])[C:4](=[O:17])[C:5]=1[NH:6][C:7]1[CH:8]=[N:9][CH:10]=[C:11]([C:13]([F:16])([F:15])[F:14])[CH:12]=1.N1([CH:28]([NH:39][C:40](=[O:48])[C:41]2[CH:46]=[CH:45][C:44]([Cl:47])=[CH:43][CH:42]=2)[C:29]([CH3:38])([CH3:37])[CH2:30][C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)C2C=CC=CC=2N=N1.C([O-])([O-])=O.[K+].[K+]>>[Cl:47][C:44]1[CH:45]=[CH:46][C:41]([C:40]([NH:39][CH:28]([NH:1][C:2]2[C:3](=[O:18])[C:4](=[O:17])[C:5]=2[NH:6][C:7]2[CH:8]=[N:9][CH:10]=[C:11]([C:13]([F:15])([F:16])[F:14])[CH:12]=2)[C:29]([CH3:37])([CH3:38])[CH2:30][C:31]2[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=2)=[O:48])=[CH:42][CH:43]=1