Morpholine → HCID 11062669, compound

HRID 2299168Notes

Reaction equation

HRID 2299168 reaction equation
[H-].[Na+].[C:3]([O:8]C)(=O)[C@H:4]([CH3:6])[OH:5].[NH:10]1[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1>C1(C)C=CC=CC=1>[OH:5][C@@H:4]([CH3:6])[C:3]([N:10]1[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1)=[O:8]

Participants

5

Reactant 3

HCID 8083MorpholineHCID 24758Sodium hydrideHCID 94386methyl (S)-lactate

Product 1

HCID 11062669HCID 11062669, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Under a nitrogen atmosphere, 60% sodium hydride (1.92 g, 0.048 mol) was added slowly portionwise to a mixture of methyl L-lactate (50.0 g, 0.48 mol) and morpholine (46 mL, 0.528 mol) with stirring in an ice-bath, and the resulting mixture was stirred at 50° C. for 3 hours. Toluene was added thereto and evaporated under reduced pressure. This procedure was repeated further twice to give B-1.

Workup

  1. stirringthe resulting mixture was stirred at 50° C. for 3 hours
  2. customevaporated under reduced pressure
  3. customto give B-1

Sources & evidence

ORD record
ord-caa730e81b6842cd986fa25b6618b285
Source dataset
uspto-grants-2002_12
Patent number
US06495587B1

Reaction notes

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